Stephen is an experienced supervisor with 20 students successfully complete PhDs under his supervision. In particular, he takes a molecular and cellular approach to understanding the factors which give rise to aberrations in signalling pathways that underlie the immune pathology associated with diseases such as rheumatoid arthritis, lupus, vasculitis and uveitis. Dr. Stephen C Young, MD is a doctor primarily located in Midlothian, VA, with another office in Midlothian, VA.

In particular, he takes a molecular and cellular approach to understanding the factors which give rise to aberrations in signalling pathways that underlie the immune pathology associated with diseases such as rheumatoid arthritis, lupus, vasculitis and uveitis. © 2005 - 2020 WebMD LLC. He is applying these methods to analysis of rheumatoid arthritis, Lupus and Behcet’s Disease in close collaboration with the RA-MAP, RACE, ARUK Microbiome and MASTERPLANS consortia. Signalling aberrations in inflammatory disease. All rights reserved. 804.741.2812   F: 804.741.4193. 1107 Westbriar Drive   Richmond, Virginia  23238 PLOS Negl Trop Dis 10(4):e0004604, Jutley GS and Young SP (2015) Metabolomics to identify biomarkers and as a predictive tool in inflammatory diseases.

He received the President's Award for achieving the highest GPA in the natural sciences in his graduating class. Traci Harrison Virginia Commonwealth University School Of Medicine, 7650 E Parham Rd Ste 210, Richmond, VA, 23294, 348 Browns Hill Ct, Midlothian, VA, 23114. He is interested in supervising doctoral research students in the following areas: If you are interesting in studying any of these subject areas please contact Stephen on the contact details above, or for any general doctoral research enquiries, please email: or call +44 (0)121 414 5005. United Kingdom, Main Switchboard: Dr. Young is a member of many professional dental organizations. In particular, he takes a molecular and cellular approach to understanding the factors which give rise to aberrations in signalling pathways that underlie the immune pathology associated with diseases such as rheumatoid arthritis, vasculitis and uveitis. Rheumatology (Oxford) 54(12):2124-5, Hou TZ, Qureshi OS, Wang CJ, Baker J, Young SP, Walker LS and Sansom DM (2015) A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells. Best Pract Res Clin Rheumatol 29(6):770-82, McGrath CM and Young SP (2015) Lipid and Metabolic Changes in Rheumatoid Arthritis. His specialties include Diabetes, Endocrinology, Diabetes & Metabolism, Internal Medicine. I also agree to

Sign Up to Receive Our Free Coronavirus Newsletter, Claim your In particular TNF, acting through acid sphingomyelinase, suppresses plasma membrane calcium signals and oxidation leads to inactivation of protein tyrosine phosphatases (PTP). In support of our mission, we offer a modern, technologically advanced environment that is optimized for patient safety, comfort, and convenience. He returned to the UK to the Liver Centre at King’s College Hospital in London before joining the Department of Rheumatology in Birmingham in 1985 as a Lecturer. Through advanced education, and training, we continually work to provide our patients with the best patient care modern dentistry has to offer. The impact of inflammation on metabolomic profiles in patients with arthritis. He has shown that the earliest stages of the atherosclerotic process, the induction of endothelial cell dysfunction, can be mediated by TNF-induced sphingomyelinase, which in turn can be regulated by oxidative stress. He spends numerous hours each year in continuing education, so he can provide his patients with the most current procedures and techniques. Dr. Young is a certified CEREC Trainer, a CEREC Beta Tester, as well as a CEREC Mentor. For more information about the oral and maxillofacial surgery services we provide, or to schedule a consultation, call our office in Johnston, RI at Oral Surgery Office of Dr. Steven Young in Johnston RI Phone Number 401-273-7802. He developed and was lead on the MSc in Rheumatology and coordinated the MSc in Immunology for a number of years. Our practice is committed to delivering the very best in patient care. Stephen’s research centres on the complex processes that give rise to chronic inflammatory diseases in humans.

You should verify the accuracy of the information directly with Dr. Stephen M Young's office or contact the doctor at 2 Medical Center Drive, Suite 308, Springfield, Massachusetts. Metabolomics of inflammation; immune cell signalling dysregulation in chronic disease. Stephen Young qualified with a BSc (Hons) in Applied Chemistry from the Hatfield Polytechnic in 1973. Dr. Young received his Bachelor of Science in Chemistry from Hampden-Sydney College in 1983. Dr. Stephen S. Young By clicking "Subscribe," I agree to the WebMD Terms and Conditions and Privacy Policy. profile, Fractures, Dislocations, Derangement, and Sprains, Anxiety Dissociative and Somatoform Disorders, Substance Use/Substance Abuse and/or Dependency, Anthem Pathway X Tier Hosp HealthKeepers DirectAccess VA, Anthem Pathway X Tiered Hospital and Dental Prime MRF. Medical Center Stephen has established NMR-based Metabolomics to study human inflammatory disease and this has proven to be a powerful tool for stratifying patients with complex diseases such as Uveitis and Rheumatoid Arthritis, and neurological diseases. Dr. Young is affiliated with Sinai Hospital Of Baltimore, Bon Secours St Mary's Hospital and Northwest Hospital. A year out in Industry with Beecham’s Pharmaceuticals enthused him for laboratory science and its potential, and he went on to study for a PhD in Haematology/Biochemistry at University College London. Richmond, Virginia, 23238  804.741.2812, Antibiotic Premedication for Dental Treatments, Pregnancy & Your Child's Developing Teeth. For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings. Let us know if you are Dr. Stephen M Young in Springfield, MA and this information is out of date or incorrect, report a correction to update your profile.

receive emails from WebMD and I understand that I may opt out of WebMD subscriptions at Facebook Twitter Instagram LinkedIn YouTube. Abnormal function of peripheral blood T lymphocytes is characteristic of rheumatoid arthritis (RA); diminished proliferation and secretion of cytokines following in vitro mitogen stimulation are observed.

Dr. Young strives to further his education and offer his patients the best dental care through extensive knowledge and state-of-the-art equipment. He then moved to the Albert Einstein College of Medicine in New York for 3 years to work in the Department of Biophysics and the Liver Research Centre.

Many Strengths. This has led to investigations of the interactions between a variant PTP N22 gene known to associated with arrange of autoimmune disease and the extrinsic factors such as hypoxia, inflammatory mediators and cigarette smoking, as an exemplar for environmental/genetic interactions in driving autoimmune arthritis. Methodological approaches include analysis of signalling pathways at the level of the single cell, molecular interaction analysis using surface plasmon resonance and metabolite profiling using NMR-based metabolomics. He has been innovative in implementing and developing a number of novel technologies. He is a member of the Curriculum Committee for the University of Birmingham's highly-rated BMedSc course. Diabetes, Endocrinology, Diabetes & Metabolism, Endocrinology, Diabetes & Metabolism, Internal Medicine, Dr. Stephen Charles He graduated magna cum laude and an inductee into Phi Beta Kappa. He has extended this work to studies on endothelial cells in an attempt to explain the increase in cardiovascular disease associated with rheumatoid arthritis. We work hard to make sure our patients get the most out of their dental experiences with us and feel comfortable every step of the way. Institute of Inflammation and AgeingReader in Experimental Rheumatology. These include analysis of signalling pathways at the level of the single cell, molecular interaction analysis using surface plasmon resonance and metabolite profiling using NMR-based metabolomics. We value quality, efficiency, collaboration, and continuous learning.

Metabolomics is a powerful new approach to the analysis of the overall metabolic activity of an organism, which may allow generation of a composite picture resulting from these many factors. It is this set of values that shapes our practice and informs our everyday interactions. Birmingham B15 2TT He attended and graduated from Medical College Of Georgia in 2005, having over 15 years of diverse experience, especially in Pain Management. Goh YS, Necchi F, O'Shaughnessy C, Miocoli F, Gavini M, Young SP, Msefula C, Gondwe E, Mandala W, Gordon M, Saul A and MacLennan CA (2016) Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing its Failure in HIV Infection. Metabolic profiling predicts response to anti-tumor necrosis factor α therapy in patients with rheumatoid arthritis, Language, Cultures, Art History and Music, College of Life and Environmental Sciences, Geography, Earth and Environmental Sciences, Sport, Exercise and Rehabilitation Sciences, College of Engineering and Physical Sciences, See all schools, departments, research and professional services, Fellowship of the Higher Education Academy, 2007, PhD Biochemistry/Haematology, University College London, 1978, BSc (Hons) Applied Chemistry, The Hatfield Polytechnic, 1973, Gene/environment interactions promoting chronic autoimmune inflammatory diseases, Immune dysregulation in chronic inflammation and ageing, Associate Editor of the Rheumatology journal, official journal of the British Society for Rheumatology, External Examiner MSc Immunology King’s College London (2012-), External Examiner BSc Medical Sciences University of Exeter (2012-). He is a keen promoter of the need to provide good quality information about their condition to patients with chronic diseases and established the first comprehensive WWW service about arthritis. Dr Young has been able to use serum metabolic profile from very early arthritis (within 3 months of symptom onset) to discriminate between those who have a self-limiting disease and those who develop a chronic arthritis. Organizations include: American Dental Association, Virginia Dental Association, Richmond Dental Society, the American Academy of Impact Dentristry, Academy of General Dentistry, American Academy of Cosmetic Dentistry and the Virginia Academy of Dental Sleep Medicine. Dr Young's research centers on the complex processes that give rise to chronic inflammatory diseases in humans. Recently his focus has been on the role of PTPN22 variants in altering immune cell function and how this gene responds to hypoxia and cigarette smoke. Pathomx: An interactive workflow-based tool for the analysis of metabolomic data. He has 33 years of experience. Click on the link below to listen to a Rheumatology Podcast where Stephen Young discusses with Prof Rob Moots, Editor of Rheumatology, a paper on antibodies formed in patients against an import therapeutic drug infliximab.

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